Insomnia Treatment and Health Care

Sertraline-naltrexone combination therapy reduced the incidence of depression, and increasing time of abstinence and alcohol-free period in patients who suffer from depression and alcohol dependence. Conclusion This is the result of research of dr. Helen M. Pettinati and colleagues from the Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, USA.

Until now, no empirical evidence that is strong enough to support the provision of antidepressants as a treatment for patients who suffer from depression and alcohol dependence. Although many studies show that antidepressants reduce depression symptoms in patients who suffer from depression and alcohol dependence, in general, antidepressant drug treatment does not seem beneficial in reducing alcohol drinking habits in these depressed patients.

A double-blind study, placebo-controlled trial conducted to examine the effectiveness of combination therapy of depression (sertraline) and alcohol dependence (naltrexone) in patients suffering from depression and alcohol dependence. This study involved 170 patients with depression, alcohol dependence were randomly divided into 4 groups: group I (n = 40) treated with sertraline 200 mg daily; group II were treated with naltrexone 100 mg daily (n = 49); group III were treated with a combination of sertraline -naltrexone 200/100 mg (n = 42), and group IV were treated with double placebo (n = 39). Therapy lasted for 14 weeks and during the therapy progresses, patients also were given cognitive and behavioral therapy (cognitive-behavioral therapy).

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