Without Tobacco Smoke Damaged DNA and Enzymes
Smokeless tobacco, it turns out, also has a bad effect not only for the mouth but also have an impact on enzyme function. According to reports monthly journal Chemical Research in Toxicology, published by the American Chemical Society, tobacco affects the function of an important group of enzymes found in nearly every organ in the body.This enzyme plays an important role in the production of hormones, including sex hormones estrogen and testosterone, the production of cholesterol and vitamin D, as well as help the body break down toxic substances. Smokeless tobacco is also damaging the genetic material in the liver, kidneys, and lungs.
Krishan Khanduja and colleagues noted the harmful effects of tobacco use without any of the mouth, including increased risk of gum disease and oral cancer. Carcinogens and other chemicals result of chewing tobacco will be absorbed into the blood and circulate throughout the body. However, scientists have little information about the effects of smokeless tobacco on the part of the body. To fill this knowledge gap, researchers evaluated changes in enzymes and genetic material that occurs in mice in the laboratory with smokeless tobacco extract. They also found that smokeless tobacco extracts alter the function of group-450 enzyme called CYP enzymes. The majority of tobacco users did not realize its impact. “The use of tobacco to ‘treat’ dental pain, headache, and abdominal pain only a false impression,” the report said. Use of smokeless tobacco increased not only among adults. But also children, adolescents, women, and immigrants from South Asia.